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pentobarbital will lessen the extent or effect of voriconazole by affecting hepatic enzyme CYP2C9/10 metabolism. Minimal/Importance Unknown.pentobarbital decreases levels of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can decrease panobinostat stages by ~70% and produce therapy failu